<i>Akkermansia muciniphila</i>-directed polyphenol chlorogenic acid intervention for obesity in mice

Akkermansia muciniphila (A. muciniphila) play an important in ameliorating obesity but is not allowed for direct consumption most countries. To date, microbiota-directed foods selectively promote the targeted human gut microbes, providing a strategy A. enhancement. Multiple studies have indicated potential regulation of polyphenol on muciniphila. Therefore, screening based upregulation was performed mice. Chlorogenic acid (CGA) exhibited greater response to upregulation. Furthermore, we found that CGA did directly growth or mucin secretion. Microbiome and metabolomics revealed increased abundance resulted from inhibition Desulfovibrio Alistipes influence docosahexaenoic acid, β-hydroxybutyrate, N-acetyl-lactosamine. Finally, confirm under disease conditions, high-fat diet-fed mice were established. The results showed promoted growth, expectedly suppressed augment body weight mice, significantly attenuated adipose tissue abnormality, provided liver protection improved barrier integrity. These suggest inhibits development obesity. Overall, our indicate food promising approach treatment